Running R/Python shell/script from Excel

I’m thinking of building a workbook that will call an R script from inside VBA.

Will converting the workbook to an EXE file using XLSPadlock after the ability to run R/Python scripts?

No, but you may have to update your VBA code to have the correct location to your R script. For instance, use the PathToFile VBA API extension:
https://www.xlspadlock.com/doc/topics/get-the-path-to-a-file-in-the-same-folder-as-the-compiled-workbook.htm