XLS Padlock with Yubikey and generic FIDO U2F Security Key

Is it possible to add Yubikey or a generic FIDO U2F Security Key as additional option for protection with hard keys?
Protection with USB stick is not good enough since these sticks are easily to be cloned.
Going with Enky SL dongle only is not really a good business decision since we hardly get a good deal with that single player in the market, or worst Enky might go out of business then we would be stuck.